The history of Radboud University Medical Center goes all the way back to the year 1905. In 1905, the Radboud Stichting (Radboud Foundation) was founded. The Radboud Stichting aimed to found a catholic university in the Netherlands. In 1923, this goal became reality. The Katholieke Universiteit Nijmegen (Catholic University Nijmegen) started off with three faculties. In 1951, the university started a medical faculty as well.

The Radboud Stichting opened an academic hospital in 1956: the Sint Radboud Ziekenhuis (Radboud Hospital). Students of the medical faculty got the opportunity to experience practical education. In 1999 the Sint Radboud Ziekenhuis transformed into a new organization: the Universitair Medisch Centrum St Radboud (University Medical Centre St Radboud), or UMC St Radboud. The catholic university also got a new name in 1999: Radboud Universiteit Nijmegen (Radboud University Nijmegen). Despite the changes of name, the co-operation between the Radboud University and the Radboud University Medical Center never faded. In 2013 the hospital underwent its most recent change of name: Radboudumc (Radboud University Medical Center).